IKKγ Monoclonal Antibody (Clone 72C627)-单抗-ELISA_抗体_蛋白_核苷酸

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IKKγ Monoclonal Antibody (Clone 72C627)

品牌：Cayman

官网链接

说明书

折扣/货期

货号：13931

规格：1 ea

目录价：￥6048

产品详情

产品名称:

IKKγ Monoclonal Antibody (Clone 72C627)

别名:

IKK3|NEMO|NF-κB Essential Modulator

产品描述:

Nuclear Factor-κB (NF-κB) is sequestered in the cytoplasm by the IκB family of inhibitory proteins that mask the nuclear localization signal of NF-κB, thereby preventing translocation of NF-κB to the nucleus.{18540} External stimuli such as tumor necrosis factor or other cytokines result in phosphorylation and degradation of IκB, releasing NF-κB dimers. NF-κB dimers subsequently translocate to the nucleus and activate target genes. Synthesis of IκBα is autoregulated.{18541} IκB proteins are phosphorylated by IκB kinase complex consisting of at least three proteins, IKK1/α, IKK2/β, and IKK3/γ.{18542,18543,18544,18658,18545} IKKγ preferentially interacts with IKKβ and is required for activation of IKK complex. IKKγ is also known as NF-κB essential modulator (NEMO).{18545} The human T cell leukemia virus type I Tax oncoprotein that activates NF-κB binds neither to IKKα nor IKKβ, but complexes directly with IKKγ.{18659} This suggests that IKKγ may be a key molecule acting as an adapter for oncoprotein specific signaling to IKKα and IKKβ.{18659}

宿主来源:

Mouse

实验应用:

同种型:

IgG1

免疫原:

His-tagged full length human IKKγ

克隆号:

72C627

保存温度:

-20

运输温度: