货号:13931 | 规格:1 ea | 目录价:¥6048 |
产品详情
产品名称:
IKKγ Monoclonal Antibody (Clone 72C627)
别名:
IKK3|NEMO|NF-κB Essential Modulator
产品描述:
Nuclear Factor-κB (NF-κB) is sequestered in the cytoplasm by the IκB family of inhibitory proteins that mask the nuclear localization signal of NF-κB, thereby preventing translocation of NF-κB to the nucleus.{18540} External stimuli such as tumor necrosis factor or other cytokines result in phosphorylation and degradation of IκB, releasing NF-κB dimers. NF-κB dimers subsequently translocate to the nucleus and activate target genes. Synthesis of IκBα is autoregulated.{18541} IκB proteins are phosphorylated by IκB kinase complex consisting of at least three proteins, IKK1/α, IKK2/β, and IKK3/γ.{18542,18543,18544,18658,18545} IKKγ preferentially interacts with IKKβ and is required for activation of IKK complex. IKKγ is also known as NF-κB essential modulator (NEMO).{18545} The human T cell leukemia virus type I Tax oncoprotein that activates NF-κB binds neither to IKKα nor IKKβ, but complexes directly with IKKγ.{18659} This suggests that IKKγ may be a key molecule acting as an adapter for oncoprotein specific signaling to IKKα and IKKβ.{18659}
宿主来源:
Mouse
实验应用:
WB
同种型:
IgG1
免疫原:
His-tagged full length human IKKγ
克隆号:
72C627
保存温度:
-20
运输温度:
-20
产品形式:
100 µg of protein G-purified IgG
有效期:
180
上一个:IκBα (Phospho-Ser32/36) Monoclonal Antibody (Clone 39A1413)
下一个:Adropin Monoclonal Antibody (Clone CC1133F5)
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