官网链接
折扣/货期| 货号：AG-40B-0241-3010 | 规格：3 x 10 ug | 目录价：￥9120 |
| 货号：AG-40B-0241-C010 | 规格：10 ug | 目录价：￥4560 |
| 货号：AG-40B-0241-C100 | 规格：100 ug | 目录价：￥19200 |
产品详情
产品名称:
IL-38 (aa 1-152) (human) (monomeric):Fc-KIH (human) (rec.) MultiPack
别名:
IL-38 (human) (monomeric):Fc Knobs-into-Holes (human) (rec.); Interleukin-38; Interleukin-1 Family Member 10; IL-1F10
产品描述:
IL-38 (IL-1F10) belongs to the IL-1 family of proteins. IL-38 is expressed in heart, placenta, fetal liver, spleen, thymus and tonsil. The expression in a variety of immune tissues and similarity to IL-1Ra suggest a role of IL-38 in the inflammatory response. It has been reported that removal of the N-terminus domain of the interleukins of the IL-1F family such as IL-1F5 / 6 / 8 or 9 (also called IL-36Ra, IL-36alpha, IL-36beta or IL-36gamma) is important to increase their biological activity. Recently it has been shown that IL-38 is N-terminally processed and secreted by apoptotic cells. Released processed IL-38 (20-152) binds to the receptor Interleukin-1 receptor accessory protein-like 1 (IL1RAPL1; TIGIRR-2) at the surface of macrophages. Processed IL-38-activated IL1RAPL1 reduces the production of IL-6 leading to inflammation attenuation. IL-38 is unregulated during some autoimmune diseases such as Systemic Lupus Erythematosus. The protein IL-38 (aa 1-152) (human) (monomeric):Fc-KIH (human) (rec.) is produced by using two different vectors, one encoding for the IL-38 (aa 1-152) (human):Fc Knobs sequence (synthesizing a protein of 45kDa) and one encoding for the Fc Holes sequence (synthesizing a protein of 28kDa). Both vectors transfected into HEK293 cells produce both Fc molecules (Knobs-into-Holes technology; J.B. Ridgway, et al.; Protein Eng. 9, 617 (1996)) required for dimerization of the Fc moieties and for secretion of the final protein IL-38 (aa 1-152) (human)(monomeric):Fc-KIH (human) (rec.).
宿主来源:
HEK 293 cells
产品浓度:
After reconstitution:for 10µg size: 0.1mg/mlfor 100µg size: 1mg/ml
保存温度:
-20°C
运输温度:
BLUE ICE
预期分子量:
~53kDa and 28kDa (SDS-PAGE)
产品形式:
solid
存储溶液:
Lyophilized. Contains PBS.
有效期:
Stable for at least 6 months after receipt when stored at -20°C.Working aliquots are stable for up to 3 months when stored at -20°C.
产地:
瑞士
纯度:
>95% (SDS-PAGE)
内毒素水平:
<0.01EU/µg protein (LAL test).
您可能感兴趣的产品
Human UFC1 protein, His tag
货号：GTX68512-pro
Human DcR2 / CD264 protein, human IgG1 Fc and His tag (active)
货号：GTX66967-pro
Mouse CTLA4 protein, mutant mouse IgG2a Fc tag (active)
货号：GTX65784-pro
Mouse TIM-4 protein, human IgG1 Fc tag (active)
货号：GTX65783-pro
Mouse TIM-1 protein, mouse IgG2a Fc tag
货号：GTX65774-pro
Mouse CD86 protein, mouse IgG2a Fc tag
货号：GTX65769-pro
Mouse CD80 protein, mouse IgG2a Fc tag
货号：GTX65767-pro
Mouse CD74 protein, mouse IgG2a Fc tag
货号：GTX65766-pro
促销活动
精品推荐
相关产品推荐
CD134 [OX40] (mouse):Fc (human) (rec.)
货号：CHI-MF-111CD134-C100
CD279 [PD-1] (mouse):Fc (human) (rec.)
货号：CHI-MF-111PD1-C100
Semaphorin-4A (mouse):Fc (human) (rec.)
货号：CHI-MF-111SEMA4-C100
Tim-1 (mouse):Fc (human) (rec.)
货号：CHI-MF-111T1-C100
Tim-2 (mouse):Fc (human) (rec.)
货号：CHI-MF-111T2-C100
Tim-4 (mouse):Fc (human) (rec.)
货号：CHI-MF-111T4-C100
