货号:18336 | 规格:100 µg | 目录价:¥4760 |
产品详情
产品名称:
N6-Methyladenosine Monoclonal Antibody (Clone 17-3-4-1)
别名:
m6A
产品描述:
N6-Methyladenosine (m6A) is an abundant modification found in mRNA, tRNA, snRNA, as well as long non-coding RNA, in all species. RNA adenosine methylation is catalyzed by a multicomponent complex composed of METTL3/MT-A70, METTL14, and WTAP in mammals. METTL3 and METTL14 are responsible for the methyltransferase activity of the complex, and WTAP mediates substrate recruitment.{30057} The process shares similarities to histone methylation in that the modification is installed by m6A methylation “writers”, detected by methylation-specific “readers”, and can be reversed by demethylation “erasers”. The m6A modification has been shown to be conserved in the vicinity of stop codons and the 3’-untranslated region of specific mouse and human mRNAs.{25677} The process of regulating m6A modifications in mammalian mRNA has been linked to disease, where fat mass and obesity-associated (FTO) has been reported to be an obesity risk gene.{25677} FTO is an m6A demethylase and polymorphisms that result in increased FTO expression are associated with increased body mass and risk of obesity. Cayman’s N6-Methyladenosine Monoclonal Antibody (Clone 17-3-4-1) can be used for dot blot, ELISA, and immunoprecipitation applications.
宿主来源:
Mouse
实验应用:
Dot blot, ELISA, IP
同种型:
IgG1k
免疫原:
N6-Methyladenosine conjugated to BSA
克隆号:
17-3-4-1
保存温度:
-20
运输温度:
-20
产品形式:
100 µg of protein A-purified antibody
有效期:
365
上一个:Histone H3K9Me2 Monoclonal Antibody (Clone 9D8)
下一个:Fibrinogen (α chain) Monoclonal Antibody (Clone 6D6)
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