NF-κB (p65) Monoclonal Antibody - Biotinylated (Clone 112A1021)-单抗-ELISA_抗体_蛋白_核苷酸

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NF-κB (p65) Monoclonal Antibody - Biotinylated (Clone 112A1021)

品牌：Cayman

官网链接

说明书

折扣/货期

货号：13756

规格：1 ea

目录价：￥6012

产品详情

产品名称:

NF-κB (p65) Monoclonal Antibody - Biotinylated (Clone 112A1021)

产品描述:

NF-κB p65 is a ubiquitously expressed transcription factor that is a subunit of the NF-κB complex and is encoded by the RELA gene in humans.{53059} It is composed of an N-terminal Rel homology domain, which contains the nuclear localization signal (NLS), and mediates dimerization, nuclear localization, and DNA and protein interactions, and two C-terminal transactivation domains that are subject to a variety of post-translational modifications and regulate the transcriptional activity of p65.{53059,53060} NF-κB p65 regulates the expression of a large number of genes in response to inflammatory and environmental cues that play critical roles in innate and adaptive immunity and cellular differentiation.{53060} Silencing of Rela induces tumor cell apoptosis in a murine Lewis lung carcinoma model, and RELA silencing in THP-1 monocytes decreases secreted levels of IL-1β and TNF-α induced by LPS.{53061,53062} Genome-wide deletion of Rela in mice is embryonic lethal.{5321} NF-κB p65 is overexpressed in the inflamed joints of patients with rheumatoid arthritis, and naïve CD4 T cells isolated from the whole blood of patients with multiple sclerosis have increased phosphorylation of NF-κB p65.{53065,53066} Cayman's NF-κB (p65) Monoclonal Antibody - Biotinylated (Clone 112A1021) can be used for ELISA applications. The antibody recognizes NF-κB (p65) at 65 kDa from human, mouse, and rat samples.

宿主来源:

Mouse

实验应用:

ELISA

同种型:

IgG1κ

免疫原:

Synthetic peptide corresponding to human NF-κB (p65)

克隆号:

112A1021

保存温度:

运输温度: