货号:13756 | 规格:1 ea | 目录价:¥6012 |
产品详情
产品名称:
NF-κB (p65) Monoclonal Antibody - Biotinylated (Clone 112A1021)
产品描述:
NF-κB p65 is a ubiquitously expressed transcription factor that is a subunit of the NF-κB complex and is encoded by the RELA gene in humans.{53059} It is composed of an N-terminal Rel homology domain, which contains the nuclear localization signal (NLS), and mediates dimerization, nuclear localization, and DNA and protein interactions, and two C-terminal transactivation domains that are subject to a variety of post-translational modifications and regulate the transcriptional activity of p65.{53059,53060} NF-κB p65 regulates the expression of a large number of genes in response to inflammatory and environmental cues that play critical roles in innate and adaptive immunity and cellular differentiation.{53060} Silencing of Rela induces tumor cell apoptosis in a murine Lewis lung carcinoma model, and RELA silencing in THP-1 monocytes decreases secreted levels of IL-1β and TNF-α induced by LPS.{53061,53062} Genome-wide deletion of Rela in mice is embryonic lethal.{5321} NF-κB p65 is overexpressed in the inflamed joints of patients with rheumatoid arthritis, and naïve CD4 T cells isolated from the whole blood of patients with multiple sclerosis have increased phosphorylation of NF-κB p65.{53065,53066} Cayman's NF-κB (p65) Monoclonal Antibody - Biotinylated (Clone 112A1021) can be used for ELISA applications. The antibody recognizes NF-κB (p65) at 65 kDa from human, mouse, and rat samples.
宿主来源:
Mouse
实验应用:
ELISA
同种型:
IgG1κ
免疫原:
Synthetic peptide corresponding to human NF-κB (p65)
克隆号:
112A1021
保存温度:
4
运输温度:
4
产品形式:
100 µg of protein G-purified IgG in 200 µl PBS containing 0.05% sodium azide
有效期:
180
来源:
Animal/Mouse
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