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折扣/货期| 货号：10784 | 规格：100 µg | 目录价：￥6720 |
产品详情
产品名称:
PAD1 (human, recombinant)
别名:
PADI1|PDI1|Peptidylarginine Deiminase 1|Protein Arginine Deiminase 1
产品描述:
Peptidyl arginine deiminase 1 (PAD1) is a calcium-dependent enzyme that catalyzes the conversion of arginine residues to citrulline within its cellular protein substrates, resulting in the loss of a positive charge, which can alter protein structure and/or function.{45610,64948} It exists as a monomer and is composed of a C-terminal catalytic domain and two N-terminal immunoglobulin-like (Ig-like) domains.{64948} PAD1 is primarily expressed in uterine and epidermal cells and generally localized in the cytosol.{19490} PAD1 citrullinates non-histone proteins, such as keratin, filaggrin, and MEK1, as well as histone H3 at arginine 2 (H3R2), H3R8, H3R17, and H4R3, to regulate epidermal cell progression and embryonic development.{64949,64950,59195} The catalytic activity of PAD1 is lost by deleting the first six N-terminal amino acids.{64948} Decreased Padi1 expression or PAD1 inhibition reduces citrullination of H3R2, H3R8, H3R17, and H4R3 and inhibits primary mouse embryo preimplantation development.{59145} PADI1 mRNA is overexpressed in tumor tissue from patients with triple-negative breast cancer (TNBC), and PAD1 promotes proliferation and epithelial-to-mesenchymal transition (EMT) in a variety of TNBC cell lines in vitro and in mouse xenograft models.{64951} Cayman's PAD1 (human, recombinant) protein can be used for enzyme activity assay and Western blot (WB) applications.
保存温度:
-80
运输温度:
-80
产品形式:
50 mM HEPES, pH 8.0, with 150 mM sodium chloride, 1 mM DTT, and 20% glycerol
有效期:
730
纯度:
≥95% estimated by SDS-PAGE
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