货号:24377 | 规格:100 µg | 目录价:¥5950 |
产品详情
产品名称:
PAD3 Monoclonal Antibody (Clone 4E5)
别名:
PADI3|PDI3|Peptidylarginine Deiminase 3|Protein Arginine Deiminase 3
产品描述:
Protein arginine deiminase 3 (PAD3) catalyzes the conversion of arginine residues to citrulline within its cellular protein substrates, which include S100A3, trichohyalin, and filaggrin, resulting in the loss of a positive charge, which can alter protein structure and/or function.{45610} It exists as a homodimer and is composed of a C-terminal catalytic domain and an N-terminal domain that contains two immunoglobulin G (IgG) subdomains.{60813} PAD3 is primarily expressed by differentiated keratinocytes in the epidermis and hair follicles where it has roles in the shaping and mechanical strengthening of hair.{60813,36391} It is also expressed by neural stem cells where it modulates cell death by regulating the nuclear translocation of apoptosis-inducing factor (AIF), in mammary glands where it citrullinates proteins during lactation, and cancer cells where it promotes cancer cell invasion.{60814,34764,60815} Mutations in PADI3 are associated with uncombable hair syndrome. Cayman's PAD3 Monoclonal Antibody (Clone 4E5) can be used for ELISA, Immunofluorescence (IF) and Western blot (WB) applications. The antibody recognizes PAD3 at ~74 kDa from human samples.
宿主来源:
Mouse
实验应用:
ELISA, IF, WB
同种型:
IgG1
免疫原:
Full length recombinant PAD3
克隆号:
400000
保存温度:
-20
运输温度:
-20
产品形式:
100 µg of protein G affinity-purified monoclonal antibody
有效期:
1095
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