PAD3 Monoclonal Antibody (Clone 4E5)-单抗-ELISA_抗体_蛋白_核苷酸_试剂盒-深圳欣博盛生物科技有限公司

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PAD3 Monoclonal Antibody (Clone 4E5)

品牌：Cayman

官网链接

说明书

折扣/货期

货号：24377

规格：100 µg

目录价：￥5950

产品详情

产品名称:

PAD3 Monoclonal Antibody (Clone 4E5)

别名:

PADI3|PDI3|Peptidylarginine Deiminase 3|Protein Arginine Deiminase 3

产品描述:

Protein arginine deiminase 3 (PAD3) catalyzes the conversion of arginine residues to citrulline within its cellular protein substrates, which include S100A3, trichohyalin, and filaggrin, resulting in the loss of a positive charge, which can alter protein structure and/or function.{45610} It exists as a homodimer and is composed of a C-terminal catalytic domain and an N-terminal domain that contains two immunoglobulin G (IgG) subdomains.{60813} PAD3 is primarily expressed by differentiated keratinocytes in the epidermis and hair follicles where it has roles in the shaping and mechanical strengthening of hair.{60813,36391} It is also expressed by neural stem cells where it modulates cell death by regulating the nuclear translocation of apoptosis-inducing factor (AIF), in mammary glands where it citrullinates proteins during lactation, and cancer cells where it promotes cancer cell invasion.{60814,34764,60815} Mutations in PADI3 are associated with uncombable hair syndrome. Cayman's PAD3 Monoclonal Antibody (Clone 4E5) can be used for ELISA, Immunofluorescence (IF) and Western blot (WB) applications. The antibody recognizes PAD3 at ~74 kDa from human samples.

宿主来源:

Mouse

实验应用:

ELISA, IF, WB

同种型:

IgG1

免疫原:

Full length recombinant PAD3

克隆号:

400000

保存温度:

-20