产品描述:
ZCL 278 is a cell-permeable inhibitor of Cdc42, a Rho family GTPase.{32673} It binds into the surface groove on Cdc42 (Kd = 6.4-11.4 µM), blocking interaction with intersectin (ITSN), a guanine nucleotide exchange factor (GEF).{32673} It inhibits Cdc42-mediated microspike formation and neuronal branching in 3T3 fibroblast and neonatal cortical neurons, respectively.{32673} ZCL 278 also exhibits potent antiviral activity by inhibiting cellular entry of Junin virus (JUNV) and other enveloped viruses into cells and inhibiting viral replication in mice.{32672}