Progesterone Receptor (Phospho-Ser294) Monoclonal Antibody-单抗-ELISA_抗体_蛋白_核苷酸

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Progesterone Receptor (Phospho-Ser294) Monoclonal Antibody

品牌：Cayman

官网链接

说明书

折扣/货期

货号：10009763

规格：1 ea

目录价：￥6736

产品详情

产品名称:

Progesterone Receptor (Phospho-Ser294) Monoclonal Antibody

产品描述:

There is accumulating evidence to suggest that progesterone plays an essential role in the regulation of growth and differentiation of mammary glands and thus may play a key role in breast cancer.{14655} The biological response to progesterone is mediated by two distinct forms of the human progesterone receptor (PR-A and PR-B forms). In most cell contexts, the B form functions as a transcriptional activator, whereas the A form functions as a transcriptional inhibitor of steroid hormones.{14653,14656} Recently it has been demonstrated that there is differential hormone dependent regulation of the phosphorylation of the A and B forms of the receptor.{14654} Treatment of T47D breast cancer cells with progestin agonist increases the phosphorylation of Ser190 and Ser294 with different kinetics. These phosphorylation events may differentially affect the transcriptional activity of the receptor.

宿主来源:

Mouse

实验应用:

WB and IHC (frozen sections)

免疫原:

phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser294 of human progesterone receptor

保存温度:

-20

运输温度:

-20

产品形式:

Peptide affinity-purified antibody