PtdIns-(3,4,5)-P3 Binding Protein-其他天然蛋白-ELISA_抗体_蛋白_核苷酸

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PtdIns-(3,4,5)-P3 Binding Protein

品牌：Cayman

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说明书

折扣/货期

货号：10009817-100 µg	规格：100 µg	目录价：￥6664
货号：10009817-25 µg	规格：25 µg	目录价：￥1974
货号：10009817	规格：50 µg	目录价：￥3542

产品详情

产品名称:

PtdIns-(3,4,5)-P3 Binding Protein

别名:

产品描述:

Pleckstrin homology (PH) domains all contain a seven-standard β-sandwich that allows binding to various species of phosphatidyl inositol (PtdIns) phosphates.{15263} Most PH domains bind to PtdIns phosphates with weak affinity and low specificity. However, a small subclass binds specifically and with high-affinity for certain PtdIns phosphates. PtdIns-(3,4,5)-P3 Binding Protein contains a highly specific PH domain that recognizes and binds PtdIns-(3,4,5)-P3 (see Figure 1).{15107} PtdIns phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals.{4096, 8344} PtdIns-(4,5)-P2 can be phosphorylated by phosphoinositide (PI)-3-kinase to make PtdIns-(3,4,5)-P3 which initiates an intricate signalling cascade that has been implicated in cancer.{12235} Due to PtdIns-(3,4,5)-P3 binding protein · s unique affinity for PtdIns-(3,4,5)-P3, this protein can be used to detect product formed by PI3-kinase in in vitro assays. Cayman’s PtdIns-(3,4,5)-P3 Binding Protein is isoform 2, which differs from isoform 1 by the absence of a glycine residue at position 277.

保存温度:

-80

运输温度:

-80

产品形式:

A solution in PBS, pH 7.4, containing 20% glycerol

有效期:

365

纯度:

≥95%

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