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折扣/货期| 货号：10009815-100 µg | 规格：100 µg | 目录价：￥6062 |
| 货号：10009815-25 µg | 规格：25 µg | 目录价：￥1694 |
| 货号：10009815 | 规格：50 µg | 目录价：￥3220 |
产品详情
产品名称:
PtdIns-(4,5)-P2 Binding Protein (GST-tagged)
别名:
Phosphatidylinositol-4,5-diphosphate|PI(4,5)-P2|PI(4,5)P2 Binding Protein|PIP2|PIP2[4',5'] Binding Protein|PLC-δ1-PH Domain
产品描述:
Pleckstrin homology (PH) domains all contain a seven-standard b-sandwich that allows binding to various species of phosphatidylinositol (PtdIns) phosphates.{15263} Most PH domains bind to PtdIns phosphates with weak affinity and low specificity. However, a small subclass binds specifically and with high-affinity for certain PtdIns phosphates. PtdIns-(4,5)-P2 Binding Protein (GST-tagged) contains a highly specific PH domain that recognizes and binds PtdIns-(4,5)-P2 (see Figure 1).{15107} PtdIns phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals.{4096, 8344} PtdIns-(4,5)-P2 can be phosphorylated by phosphoinositide (PI)-3-kinase to make PtdIns-(3,4,5)-P3 which initiates an intricate signaling cascade that has been implicated in cancer{12235} PtdIns-(4,5)-P2 binding protein can be used in in vitro assays for the detection of PtdIns-(4,5)-P2 in PI3-kinase and PTEN phosphatase assays.
保存温度:
-80
运输温度:
-80
产品形式:
A solution in PBS, pH 7.4, containing 20% glycerol
有效期:
365
纯度:
≥90%
上一个:Copper (Cu++) Oxidized Human Low Density Lipoprotein (LDL)
下一个:PtdIns-(3,4,5)-P3 Binding Protein
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