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折扣/货期| 货号：10009563 | 规格：25 µg | 目录价：￥5446 |
产品详情
产品名称:
sPLA2 (human, recombinant Type V)
别名:
gVPLA2|Phosphatidylcholine 2-acylhydrolase 5|PLA2G5|Secretory Phospholipase A2 (Group V)
产品描述:
Phospholipase A2 (PLA2) catalyzes the hydrolysis of fatty acids at the sn-2 position of glycerophospholipids. PLA2 (Type V) is a secretory PLA2 (sPLA2) of approximately 14 kDa and is one of the isoforms in the growing list of the PLA2 enzyme family.{11139} This enzyme, rather than the sPLA2 (Type II), is responsible for arachidonic acid mobilization leading to prostaglandin production in macrophages and mast cells.{3506,4455,4053} Consistent with this role, sPLA2 (Type V) is associated with the golgi apparatus, nuclear envelope, and plasma membrane in mouse bone marrow-derived mast cells.{7627} sPLA2 (Type V) has been cloned from a variety of species including human, mouse, and rat.{7748,5754,7749} The enzyme is expressed in heart, lung, placenta, and spleen, as well as P388D1 macrophages and mast cells.{3506,4455,7749} The specific activity of Cayman’s sPLA2 (human, recombinant Type V) was established using 1,2-bis(heptanoylthio) Glycerophosphocholine (Cayman Item No. 62235) as the substrate. The reaction was inhibited by thioetheramide-PC (Cayman Item No. 62750).
保存温度:
-80
运输温度:
-80
产品形式:
50 mM Tris-HCl, pH 8.0, containing 100 mM sodium chloride, 50 mM calcium chloride, and 20% glycerol
有效期:
365
纯度:
≥95% estimated by SDS-PAGE
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