Tim-3 (mouse):Fc (mouse) (rec.)-Fc融合蛋白-ELISA_抗体_蛋白_核苷酸

首页产品中心 Fc融合蛋白

Tim-3 (mouse):Fc (mouse) (rec.)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：CHI-MF-110T3-C100

规格：100 ug

目录价：￥6160

产品详情

产品名称:

Tim-3 (mouse):Fc (mouse) (rec.)

别名:

TIM3; TIMD3; Hepatitis A Virus Cellular Receptor 2; HAVcr-2; T Cell Immunoglobulin and Mucin Domain-containing Protein 3

产品描述:

The TIM (T cell/transmembrane, immunoglobulin and mucin) family plays a critical role in regulating immune responses, including allergy, asthma, transplant tolerance, autoimmunity and the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific recognition of phosphatidylserine (PtdSer), exposed on the surface of apoptotic cells. Tim-3, a type I transmembrane protein, contains an immunoglobulin and a mucin-like domain in its extracellular portion and a tyrosine phosphorylation motif in its cytoplasmic portion. TIM-3 is preferentially expressed on Th1 and Tc1 cells, and generates an inhibitory signal resulting in apoptosis of Th1 and Tc1 cells. TIM-3 is also expressed on some dendritic cells and can mediate phagocytosis of apoptotic cells and cross-presentation of antigen. Tim-3 functions to inhibit aggressive Th1-mediated auto- and alloimmune responses. Tim-3 pathway blockade by administration of Tim-3:Fc fusion protein accelerates diabetes in nonobese diabetic mice, causes hyperproliferation of Th1 cells and Th1 cytokine release in an experimental autoimmune encephalomyelitis (EAE) model and prevents acquisition of transplantation tolerance induced by costimulation blockade.

宿主来源:

HEK 293 cells

保存温度:

-20°C

运输温度:

BLUE ICE

预期分子量:

~65kDa (SDS-PAGE)

产品形式:

solid

存储溶液:

Lyophilized from 0.2µm-filtered solution in PBS.

有效期:

Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

产地:

瑞士

纯度:

>98% (SDS-PAGE)

生物活性:

Immobilized recombinant human Galectin-9 at 500ng/ml can bind Tim-3 (mouse):Fc (human) (rec.) with an apparent KD <10nM. Optimal dilutions should be determined by each laboratory for each application.

内毒素水平:

<5EU/mg protein (LAL test; Lonza).

您可能感兴趣的产品

Human UFC1 protein, His tag

货号：GTX68512-pro

Human DcR2 / CD264 protein, human IgG1 Fc and His tag (active)

货号：GTX66967-pro

Mouse CTLA4 protein, mutant mouse IgG2a Fc tag (active)

货号：GTX65784-pro

Mouse TIM-4 protein, human IgG1 Fc tag (active)

货号：GTX65783-pro

Mouse TIM-1 protein, mouse IgG2a Fc tag