Toll-Like Receptor 2 Monoclonal Antibody (Clone TL2.1)-单抗-ELISA_抗体_蛋白_核苷酸

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Toll-Like Receptor 2 Monoclonal Antibody (Clone TL2.1)

品牌：Cayman

官网链接

说明书

折扣/货期

货号：13587

规格：1 ea

目录价：￥6390

产品详情

产品名称:

Toll-Like Receptor 2 Monoclonal Antibody (Clone TL2.1)

别名:

TLR2

产品描述:

The toll-like receptors (TLRs) in mammals comprise a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and an interleukin-1 (IL-1) receptor motif in the cytoplasmic domain. Like their counterparts in Drosophila, TLRs signal through adaptor molecules.{17463} The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition.{17464} Most mammalian species have between ten and fifteen types of TLRs. Ten functional TLRs (TLR1-10) have been identified in human. Humans also encode a TLR11 gene but it contains several stop codons and protein is not expressed. However, murine and rat TLR11 are functional, and it is thought that human TLR11 function was lost during evolution. TLR2 is differentially expressed in human cells. Historically speaking, TLR expression has been most extensively studied in the immune system. Overall, TLRs are highly expressed in immune competent cells, including macrophages, dendritic cells, neutrophils, mucosal epithelial cells, and dermal endothelial cells. However, TLRs have also been identified in many other cell types and anatomical tissue locations where they are expressed either constitutively or induced during infection.

宿主来源:

Mouse

实验应用:

FC (intracellular and cell surface), IP, and IHC

同种型:

IgG2a

免疫原:

CHO cells transfected with human TLR2 cDNA

克隆号:

TL2.1

保存温度:

-20