货号:13587 | 规格:1 ea | 目录价:¥6390 |
产品详情
产品名称:
Toll-Like Receptor 2 Monoclonal Antibody (Clone TL2.1)
别名:
TLR2
产品描述:
The toll-like receptors (TLRs) in mammals comprise a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and an interleukin-1 (IL-1) receptor motif in the cytoplasmic domain. Like their counterparts in Drosophila, TLRs signal through adaptor molecules.{17463} The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition.{17464} Most mammalian species have between ten and fifteen types of TLRs. Ten functional TLRs (TLR1-10) have been identified in human. Humans also encode a TLR11 gene but it contains several stop codons and protein is not expressed. However, murine and rat TLR11 are functional, and it is thought that human TLR11 function was lost during evolution. TLR2 is differentially expressed in human cells. Historically speaking, TLR expression has been most extensively studied in the immune system. Overall, TLRs are highly expressed in immune competent cells, including macrophages, dendritic cells, neutrophils, mucosal epithelial cells, and dermal endothelial cells. However, TLRs have also been identified in many other cell types and anatomical tissue locations where they are expressed either constitutively or induced during infection.
宿主来源:
Mouse
实验应用:
FC (intracellular and cell surface), IP, and IHC
同种型:
IgG2a
免疫原:
CHO cells transfected with human TLR2 cDNA
克隆号:
TL2.1
保存温度:
-20
运输温度:
-20
产品形式:
100 µg of protein G-purified IgG in 200 µl PBS containing 0.05% BSA and 0.05% sodium salt
有效期:
365
来源:
Animal/Mouse
上一个:PARP (Cleaved) Monoclonal Antibody
下一个:Toll-Like Receptor 3 Monoclonal Antibody (Clone 40C1285.6)
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