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折扣/货期| 货号：AG-40B-0164-C050 | 规格：50 ug | 目录价：￥3360 |
产品详情
产品名称:
VISTA [B7-H5] (mouse):Fc (human) (rec.)
别名:
V-type Immunoglobulin Domain-containing Suppressor of T Cell Activation; Platelet Receptor Gi24; Stress-induced Secreted Protein-1; Sisp-1; V-set Domain-containing Immunoregulatory Receptor
产品描述:
Mouse VISTA is a 55- to 65kDa type I Ig membrane protein with the extracellular domain homologous to PD-L1. VISTA is mainly expressed on hematopoietic tissues (spleen, thymus and bone marrow) and on myeloid cells with lower expression on CD4+ and CD8+ T cells. VISTA is a new negative checkpoint regulator that potently suppresses T cell activation. Overexpression of VISTA on tumors inhibits the protective anti-tumor immunity and blockade of VISTA enhances antitumor immunity in multiple tumor models. VISTA on APC delivers negative signaling to T cells via a yet-to-identify binding partner on T cells.
宿主来源:
HEK 293 cells
产品浓度:
1mg/ml after reconstitution
保存温度:
-20°C
运输温度:
BLUE ICE
预期分子量:
~65-70kDa (SDS-PAGE)
产品形式:
solid
存储溶液:
Lyophilized. Contains PBS.
有效期:
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
产地:
瑞士
纯度:
>95% (SDS-PAGE)
内毒素水平:
<0.01EU/µg purified protein (LAL test).
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