货号:CHI-HF-210CCL20-C050 | 规格:50 ug | 目录价:¥4340 |
产品详情
产品名称:
CCL20 (human):Fc (human) (rec.)
别名:
Chemokine (C-C motif) ligand 20; LARC; MIP-3A; ST38; Scya20; Exodus-1
产品描述:
Macrophage Inflammatory Protein-3 (MIP3A) or Chemokine (C-C motif) ligand 20 (CCL20) or liver activation regulated chemokine (LARC) or is a small cytokine belonging to the CC chemokine family that attracts immature dendritic cells and memory T lymphocytes, both expressing CCR6. Depending on the cell type, this chemokine was found to be inducible by cytokines (IL-1beta) and by bacterial, viral, or plant products. MIP3A / CCL20 is Expressed predominantly in the liver, lymph nodes, appendix, peripheral blood lymphocytes, and fetal lung. Low levels of MIP3A / CCL20 has been seen in thymus, prostate, testis, small intestine and colon. As a chemotactic factor, MIP3A / CCL20 attracts lymphocytes and, slightly, neutrophils, but not monocytes. This chemokine may Inhibit proliferation of myeloid progenitors in colony formation assays and it may be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. Its C-terminal processed forms have been shown to be equally chemotactically active for leukocytes. Deregulation of miRNAs and chemokine CCL20 was shown to play a role in colorectal cancer (CRC) pathogenesis and the regulation of CCL20 expression by miR-21 might be a regulatory mechanism involved in progression of colorectal cancer (CRC).
宿主来源:
HEK 293 cells
保存温度:
-20°C
运输温度:
BLUE ICE
预期分子量:
~38kDa (SDS-PAGE, reducing conditions)
产品形式:
solid
存储溶液:
Lyophilized from 0.2µm-filtered solution in PBS.
有效期:
Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
产地:
瑞士
纯度:
>95% (SDS-PAGE)
内毒素水平:
<5EU/mg protein (LAL test; Lonza).
您可能感兴趣的产品
Human UFC1 protein, His tag
货号:GTX68512-pro
Human DcR2 / CD264 protein, human IgG1 Fc and His tag (active)
货号:GTX66967-pro
Mouse CTLA4 protein, mutant mouse IgG2a Fc tag (active)
货号:GTX65784-pro
Mouse TIM-4 protein, human IgG1 Fc tag (active)
货号:GTX65783-pro
Mouse TIM-1 protein, mouse IgG2a Fc tag
货号:GTX65774-pro
Mouse CD86 protein, mouse IgG2a Fc tag
货号:GTX65769-pro
Mouse CD80 protein, mouse IgG2a Fc tag
货号:GTX65767-pro
Mouse CD74 protein, mouse IgG2a Fc tag
货号:GTX65766-pro
促销活动
精品推荐
相关产品推荐
CD134 [OX40] (mouse):Fc (human) (rec.)
货号:CHI-MF-111CD134-C100
CD279 [PD-1] (mouse):Fc (human) (rec.)
货号:CHI-MF-111PD1-C100
Semaphorin-4A (mouse):Fc (human) (rec.)
货号:CHI-MF-111SEMA4-C100
Tim-1 (mouse):Fc (human) (rec.)
货号:CHI-MF-111T1-C100
Tim-2 (mouse):Fc (human) (rec.)
货号:CHI-MF-111T2-C100
Tim-4 (mouse):Fc (human) (rec.)
货号:CHI-MF-111T4-C100