CD112R (mouse):Fc (human) (rec.) MultiPack-Fc融合蛋白-ELISA_抗体_蛋白_核苷酸

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CD112R (mouse):Fc (human) (rec.) MultiPack

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-40B-0170-3010	规格：3 x 10 ug	目录价：￥9600
货号：AG-40B-0170-C010	规格：10 ug	目录价：￥4800

产品详情

产品名称:

CD112R (mouse):Fc (human) (rec.) MultiPack

别名:

CD112 Receptor; Poliovirus Receptor-related Immunoglobulin Domain-containing Protein; Transmembrane Protein PVRIG

产品描述:

CD112 (also called Nectin-2 or poliovirus receptor-related 2 protein) is a type I transmembrane glycoprotein and a member of the Ig gene superfamily (IGSF). CD112/Nectin-2 functions as an adhesion molecule involved in the formation of cell junctions and interactions with other Nectin-family molecules. Nectin-2 is a also a surface marker of some endothelial cells and regulates migration, proliferation and angiogenesis. CD112 functions as an immune checkpoint regulator by modulating T cell signaling, either as a costimulator of T cell function, or as a coinhibitor of T cells proliferation by binding to the receptors CD226 or TIGIT (T cell Ig and immunoreceptor tyrosine-based inhibitory motif (ITIM) domain), respectively. The binding of CD112 ligand to these receptors is weak compared to CD155. Recently, a new receptor of CD112, called CD112R or PVRIG (Poliovirus receptor-related immunoglobulin domain-containing protein) has been characterized, showing high affinity to CD112. CD112R is a new coinhibitory receptor of the PVR family for human T cells, inhibiting TCR-mediated signals upon binding to CD112/Nectin-2. CD112R is preferentially expressed in T lymphocytes and NK cells. Cancer cells evade immune responses as a result of an immunosuppressive tumor microenvironment and CD112R, by playing a role in the regulation of the immune system, could be a new attractive cancer immunotherapy target.

宿主来源:

HEK 293 cells

产品浓度:

0.1mg/ml after reconstitution

保存温度:

-20°C

运输温度:

BLUE ICE

预期分子量:

~48-50kDa (SDS-PAGE)

产品形式:

solid