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折扣/货期| 货号：18473 | 规格：1 mg | 目录价：￥7630 |
产品详情
产品名称:
Human Fibrinogen (PAD2 Citrullinated)
产品描述:
Fibrinogen is a plasma clotting factor composed of three different polypeptide chains (α, β and γ). Under chronic inflammatory conditions, fibrinogen can be acted upon by the peptidylarginine deiminases enzymes (PAD2 and PAD4), converting specific arginine residues to citrulline. Patients with rheumatoid arthritis (RA) produce antibodies that bind citrullinated human fibrinogen.{21644} The citrullinated fibrinogen and reactive antibodies form immune complexes in RA patients, and these immune complexes can stimulate macrophages.{21645,21643} Immunizing certain strains of mice with citrullinated human fibrinogen can induce the production of anti-citrullinated human fibrinogen antibodies and the development of arthritis that shares many pathophysiological features of the human disease.{21646,21647}
保存温度:
-80
运输温度:
-80
产品形式:
Frozen solution in 50 mM Tris-HCl, pH 7.4, 150 mM sodium chloride, and 10% glycerol
有效期:
180
纯度:
Homogeneous by SDS-PAGE. Clottable proteins: ≥90%
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