货号:400076 | 规格:1 mg | 目录价:¥7630 |
产品详情
产品名称:
Human Fibrinogen (PAD4 Citrullinated)
产品描述:
Fibrinogen is a plasma clotting factor composed of three different polypeptide chains (α, β and γ). Under chronic inflammatory conditions, fibrinogen can be acted upon by the enzyme peptidylarginine deiminase 4 (PAD4), converting specific arginine residues to citrulline. Patients with rheumatoid arthritis (RA) produce antibodies that bind citrullinated human fibrinogen.{21644} The citrullinated fibrinogen and reactive antibodies form immune complexes in RA patients, and these immune complexes can stimulate macrophages.{21645,21643} Recently, it has been discovered that immunizing certain strains of mice with citrullinated human fibrinogen can induce the production of anti-citrullinated human fibrinogen antibodies and the development of arthritis that shares many pathophysiological features of the human disease.{21646,21647}
保存温度:
-80
运输温度:
-80
产品形式:
Frozen solution with 50 mM Tris-HCl, pH 7.4, 150 mM sodium chloride, and 10% glycerol
有效期:
180
纯度:
Homogeneous by SDS-PAGE. Clottable proteins: ≥90%
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