Human Fibrinogen (PAD4 Citrullinated)-其他天然蛋白-ELISA_抗体_蛋白_核苷酸

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Human Fibrinogen (PAD4 Citrullinated)

品牌：Cayman

官网链接

说明书

折扣/货期

货号：400076

规格：1 mg

目录价：￥7630

产品详情

产品名称:

Human Fibrinogen (PAD4 Citrullinated)

产品描述:

Fibrinogen is a plasma clotting factor composed of three different polypeptide chains (α, β and γ). Under chronic inflammatory conditions, fibrinogen can be acted upon by the enzyme peptidylarginine deiminase 4 (PAD4), converting specific arginine residues to citrulline. Patients with rheumatoid arthritis (RA) produce antibodies that bind citrullinated human fibrinogen.{21644} The citrullinated fibrinogen and reactive antibodies form immune complexes in RA patients, and these immune complexes can stimulate macrophages.{21645,21643} Recently, it has been discovered that immunizing certain strains of mice with citrullinated human fibrinogen can induce the production of anti-citrullinated human fibrinogen antibodies and the development of arthritis that shares many pathophysiological features of the human disease.{21646,21647}

保存温度:

-80

运输温度:

-80

产品形式:

Frozen solution with 50 mM Tris-HCl, pH 7.4, 150 mM sodium chloride, and 10% glycerol

有效期:

180

纯度:

Homogeneous by SDS-PAGE. Clottable proteins: ≥90%

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