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BioXcell 新品推荐:InVivoMAb anti-mouse CD28单克隆抗体

2021-04-29
浏览次数: 37

InVivoMAb anti-mouse CD28单克隆抗体


研发背景

D665单克隆抗体可与小鼠CD28反应CD28T细胞中关键的共刺激受体,同时也是Ig超家族成员之一,其主要由胸腺细胞、大部分外周血T细胞和NK细胞表达。CD28CD80 (B7-1)CD86 (B7-2)的受体。通过CD28信号传导可诱导IL-2IL-2受体表达和T细胞增殖。D665抗体是一种CD28超激动剂,在多种小鼠疾病模型中常用来诱导Treg细胞在体内的扩增。


产品信息

克隆号(Clone

D665

同种型(Isotype

Mouse IgG1

免疫原(Immunogen

A20 cells expressing mouse CD28 and a recombinant mouse CD28-Ig fusion protein

应用(Reported Applications

in vivo T cell stimulation/activation

in vitro T cell stimulation/activation

形式(Formulation

PBS, pH 7.0

Contains no stabilizers or preservatives

内毒素(Endotoxin

<2EU/mg (<0.002EU/μg)

Determined by LAL gel clotting assay

纯度(Purity

>95%

Determined by SDS-PAGE

无菌(Sterility

0.2 μM filtered

纯化(Purification

Protein G

分子量(Molecular Weight

150 kDa

储存(Storage

The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.


订购详情

产品名称

货号

规格

InVivoMAb anti-mouse CD28

BE0328

1MG5MG25MG50MG100MG


参考文献

Schmidt, T., et al. (2016). 'Induction of T regulatory cells by the superagonistic anti-CD28 antibody D665 leads to decreased pathogenic IgG autoantibodies against desmoglein 3 in a HLA-transgenic mouse model of pemphigus vulgaris.' Exp Dermatol 25(4): 293-298.

Win, S. J., et al. (2016). 'In vivo activation of Treg cells with a CD28 superagonist prevents and ameliorates chronic destructive arthritis in mice.' Eur J Immunol 46(5): 1193-1202. 

Schuhmann, M. K., et al. (2015). 'CD28 superagonist-mediated boost of regulatory T cells increases thrombo-inflammation and ischemic neurodegeneration during the acute phase of experimental stroke.' J Cereb Blood Flow Metab 35(1): 6-10.

Dennehy, K. M., et al. (2006). 'Cutting edge: monovalency of CD28 maintains the antigen dependence of T cell costimulatory responses.' J Immunol 176(10): 5725-5729. 



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